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KMID : 1161420200230080852
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Journal of Medicinal Food
2020 Volume.23 No. 8 p.852 ~ p.861
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Hepatoprotective Effects of Streptococcus thermophilus LM1012 in Mice Exposed to Air Pollutants
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Jeon Min-Gyu
Kim Tae-Rahk
Lee Ji-Yeon
Kim Hyun-Su
Ji Yosep
Holzapfel Wilhelm H.
Bae Dong-Hyuck
Choi Chul-Yung
Hwang Yong-Pil
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Abstract
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In this study, we explored whether the use of Streptococcus thermophilus LM1012 (TL-LM1012) as a safe probiotic exerts hepatoprotective effects by suppressing oxidative stress and inflammation in vitro and alleviating aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) production in vivo. In a series of safety tests, TL-LM1012 was found to have a negative response to hemolysis and biogenic amines, as well as susceptibility to antibiotics. TL-LM1012 protected cell viability and suppressed cytotoxicity by inhibiting oxidative stress and induced heme oxygenase-1 and superoxide dismutase activity in a dose-dependent manner in diesel exhaust particulate matter (DEPM)-treated HepG2 cells. Moreover, proinflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-6, and IL-1β, were suppressed in DEPM-treated splenocytes. In DEPM-treated mice, oral administration of TL-LM1012 regulated AST, ALT, and LDH production in the serum after 14 days of treatment. These findings indicate that TL-LM1012, a safe probiotic, provides a potent preventive or therapeutic effect against liver disease caused by air pollution.
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KEYWORD
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diesel exhaust particulate matter, hepatoprotective activity, inflammation, oxidative stress, Streptococcus thermophilus LM1012
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